Ping Mamiya, Ph.D.

Research Scientist

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Bio

Dr. Mamiya is a research scientist working with Dr. Patricia Kuhl on how dopamine and serotonin mediates language learning through modulation of neural activity in the prefrontal cortex. She earned her Ph.D. in Department of Biopsychology and Behavioral Neuroscience at Rutgers University where she investigated the dysfunctions of dopamine and serotonin systems in EphA5 knockout animal, and developed a nanofiber system to enhance the growth of dopaminergic neurons. Her research at I-LABS focuses on the relationship between the language learning ability and 1) polymorphism of dopamine and serotonin transporter genes and 2) the size of dopamine and serotonin projection fibers to the prefrontal cortex. By examining these relationships in both adults and infants, her research aims to further our understanding of how social interactions may facilitate language learning through dopamine/serotonin mediated modulation of prefrontal executive functions.

Visit Ping's website here.

RESEARCH INTERESTS


My research addresses two fundamental quesitons in neuroscience: 1) how does an adult human brain modify its structure during learning? and 2) how is this process controlled by the neuromodulators. I believe that the information I will gain from studying these two questions will enable me to understand the differences in individuals’ learning abilities.
To answer these two questions, I use the multimodal structural brain imaging to document how the structural changes occur in human brains in vivo, and I use the high throughput DNA sequencing to study genetic variations in genes related to the neuromodulatory systems to understand brain neuromodulator levels. I then apply biostatistical modeling to identify genetic variants that have the potential to change the brain structure during learning in individuals. Using each individual’s brain structural and genetic characteristics, I bulid biostatistical models to predict the learning outcome.

CV

EDUCATION


2006            Ph.D.            Biopsychology and Behavioral Neuroscience
                                         Rutgers – The State University of New Jersey, New Brunswick, NJ, USA
2004            M.S.             Biopsychology and Behavioral Neuroscience
                                         Rutgers – The State University of New Jersey, New Brunswick, NJ, USA
1997            B.S.              Psychology
                                         Kaoshiung Medical College, Kaoshiung, Taiwan

PROFESSIONAL TRAINING


2017            High-Troughput Biology: From Sequence to Networks           Cold Spring Harbor Laboratory
                                                                                                                    Cold Spring Harbor, NY, USA
2016            Elements of R                                                                          Summer Institute,
                                                                                                                     University of Washington
                                                                                                                     Seattle, WA, USA
2016            Association Mapping:GWAS and Sequencing Data                 Summer Institute,
                                                                                                                     University of Washington
                                                                                                                     Seattle, WA, USA
2016            Future Faculty Workshop                                                         University of Washington
                                                                                                                     Seattle, WA, USA
2015            Presentation Excellence                                                          University of Washington
                                                                                                                     Seattle, WA, USA
2015            Python Programming                                                               University of Washington
                                                                                                                     Seattle, WA, USA
2013            FSL course                                                                               FMRIB Centre,
                                                                                                                     University of Oxford
                                                                                                                     Redmond, WA, USA

AWARDS


2017            Helmsley Fellowship                                                               Cold Spring Harbor Laboratory
2016            Scholarship to attend Summer Institute                                  University of Washington,
                                                                                                                    Department of Biostatistics
2016            Scholarship to attend Gila in Health and Disease meeting     Cold Spring Harbor Laboratory
2016            Postdoctoral Travel Award                                                      University of Washington,
                                                                                                                    Office of Postdoctoral Affairs
2015            Postdoctoral Fellow Award                                                     Cognitive Neuroscience Society
1997            Ambassador Scholarship Award                                             Rotary International

GRANT


2016            Small Grant Project (Role:P1)                    Institute of Translational Health Sciences (ITHS),
                                                                                       University of Washington, Seattle, WA

UNIVERSITY TEACHING EXPERIENCES


Department of Linguistics, Rutgers University – New Brunswick, NJ, USA                      1999 - 2000
Teaching assistant for the introductory Mandarin courses; grading students; works; and leading discussion sessions.

Department of Anatomy, National Yang-Ming University, Taipei Taiwan                            1996 - 1997
Assistant lecturer for the Gross anatomy, and Human Neuroanatomy lab courses for 150 medical and dental students; performing dissection on human cadaver; designing study materials; and leading discussion sessions.

Publications

PUBLICATIONS


Mamiya, PC, Richards, T, Coe, BP, Eichler, EE and Kuhl, PK. Brain white matter structure and COMT gene are linked to second language learning in adults. Proceedings of the National Academy of Sciences of the United States of America. 2016 June 28; 113(26): 7259-54.

Mamiya, PC, Hennesey, Z, Zhou, RP, Wagner, GC. Changes in attack behavior and activity in EphA5 knockout Mice. Brain Research 2008 Apr 18: 1205:91-9.

Ahmed I, Liu HY, Mamiya PC, Ponery AS, Babu AN, Weik T, Schindler M, Meiners S. J. Three-dimensional nanofibrillar surfaces covalently modified with tenascin-C-derived peptides enhance neuronal growth in vitro. Biomed Mater Res A. 2006 Mar 15; 76(4)851-60.

Mamiya, PC, Matray-Devoti, J, Fisher, H, Wagner, GC. Mice increased target biting behaviors 24 hours after co-administration of alcohol and fluoxetine. (under minor revision).

Works in Progress

Mamiya, PC, Richards, TL, and Kuhl, PK. Ventral Tegmental Area and Cingulum Pathways Mediate Second Language Listening and Reading skills in Chinese Young Adults. (in preparation).

Mamiya, PC, Ahmed, I, Schindler, Wagner, GC and Meiners, S. Nanofiber Matrix Enhances Neurite Outgrowth and Survival of Dopamine Progenitor Cells. (in preparation).

CONFERENCE PRESENTATIONS


Mamiya, PC, Richards, TL, and Kuhl, PK. Characterizing a possible role of oligodendrocyte dependent myelination in second language learning – a brain imaging study. Glia in Health and Disease. Cold Spring Harbor Laboratory. Cold Spring Harbor, New York, USA (2016).

Mamiya, PC, Richards, TL, Coe, B, Eichler EE, and Kuhl, PK. Linking gene, brain and behavior in a study of second language learning. Annual meeting for the Cognitive Neuroscience Society. San Francisco, California, USA (2015).

Mamiya, PC, Richards, TL, Coe, B, Eichler, EE, and Kuhl, PK. Val158Met polymorphism in COMT affects the brain’s white matter properties during second language immersion. Annual meeting for The American Society of Human Genetics. Washington DC, USA (2015).

Mamiya, PC. Neural and genetic correlates of second language acquisition. The Ready Mind Project. University of Washington, Washington, USA (2014).

Mamiya, PC., Meiners, S, Schindler, M and Wagner, GC. Nanofiber matrix enhances neurite outgrowth of dopamine progenitor cells in culture. Annual meeting for the Society for Neuroscience. San Diego, California, USA (2004).

Mamiya, PC, Zhou, RP, Wagner, GC. Locomotor Activity in EphA5 Knockout Mice. Annual meeting for the Society for Neuroscience. New Orleans, Louisiana, USA (2003).

Mamiya, PC, Hennesey, Z, Zhou, RP, Wagner, GC. Aggression in EphA5 Knockout Mice. Annual meeting for the Society for Neuroscience. Orlando, Florida, USA (2002).

Mamiya, PC, Matray-Devoti, J, Fisher, H, Wagner, G.C. Delayed Increase in Defensive Aggression Following Fluoxetine. Annual meeting for the Society for Neuroscience. San Diego, California, USA (2001).

INVITED TALKS


2016 Brain structures and genetic variations jointly predict second language learning in adults.
         2016 International Mind, Brain and Education Conference, Toronto, Canada.

Contact

Phone Number: 
(206) 221-6415
Email: 
pcmamiya@uw.edu

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